TABLE 1.

In vitro susceptibilities of 771 isolates of Aspergillus spp. to four azole antifungal agents

Species (no. of isolates)Antifungal agentMIC (μg/ml)Cumulative % of isolates inhibited at MIC (μg/ml) of:
Range50%/90%0.030.060.120.250.51248
A. fumigatus (553)Itraconazole0.12-20.5/1003175193100
Posaconazole0.03-20.25/0.541737799799100
Ravuconazole0.06-40.5/0.50<13349299>99100
Voriconazole0.06-40.25/0.50<1138198>99>99100
A. flavus (76)Itraconazole0.12-20.5/1001208099100
Posaconazole0.06-20.25/0.50125759397100
Ravuconazole0.12-20.5/1001125099100
Voriconazole0.06-10.5/10142275100
A. niger (59)Itraconazole0.5->82/>800001041767878
Posaconazole0.12-20.25/10019588592100
Ravuconazole0.25-82/4000314468898100
Voriconazole0.12-20.5/1003125397100
A. terreus (35)Itraconazole0.12-10.5/0.50063497100
Posaconazole0.06-0.50.25/0.25094994100
Ravuconazole0.03-10.5/0.53394094100
Voriconazole0.06-10.25/0.50365494100
A. versicolor (24)Itraconazole0.12->81/2004173367969696
Posaconazole0.06-20.5/10821467592100
Ravuconazole0.03-20.5/18825386796100
Voriconazole0.03-20.25/14821677596100
A. nidulans (5)Itraconazole0.5-0.50.5/NAc0000100
Posaconazole0.06-0.250.12/NA02080100
Ravuconazole0.03-20.12/NA404080808080100
Voriconazole0.03-20.12/NA404080808080100
A. sydowii (4)Itraconazole0.5-42/NA0000252575100
Posaconazole0.25-10.25/NA0005075100
Ravuconazole0.25-20.25/NA000505075100
Voriconazole0.25-20.25/NA000507575100
A. calidoustus (A. ustus)a (4)Itraconazole0.12-22/NA0025252525100
Posaconazole0.25-82/NA0002525255075100
Ravuconazole0.25-21/NA000252550100
Voriconazole0.25-42/NA00025252575100
All Aspergillus isolatesb (771)Itraconazole0.12->80.5/2003175388989898
Posaconazole0.03->80.25/0.531334769598>99>99>99
Ravuconazole0.03->80.5/111430809499>99>99
Voriconazole0.03->80.25/0.51112679098>99>99>99
  • a Formerly identified as A. ustus (19).

  • b In addition to the species in the table, the total includes two A. glaucus isolates, one A. oryzae isolate, and one A. niveus isolate.

  • c NA, not applicable.