TABLE 6.

Relationship between MIC and outcome for treatment of invasive candidiasis with andidulafungin and micafungina

MIC (μg/ml)bResults for:c
AnidulafunginMicafungin
S/T%S/T%
0.00867/7096
0.01611/1479120/14981
0.0311/1385116/15276
0.068/98912/1392
0.1251/33312/1486
0.251/110015/1788
0.54/58019/2576
13/56028/3190.3
22/21005/956 (71)d
Total119/13588327/41080
Total ≤2119/13588327/41080
  • a Data were compiled from references 30, 45, and 56.

  • b MICs were determined in accordance with the standards of CLSI document M27-A3 (11). Total ≤2, total number of patients for whose isolates the drug MIC was 2 μg/ml or less.

  • c S/T, number of patients successfully treated/total number treated.

  • d Five of 7 patients infected with C. parapsilosis for which the MIC was 2 μg/ml were treated successfully.