TABLE 2.

In vitro susceptibilities of 771 isolates of Aspergillus spp. to posaconazole, ravuconazole, and voriconazole with respect to itraconazole susceptibility

Itraconazole category (no. of isolates)Antifungal agentMIC (μg/ml)Cumulative % of isolates inhibited at MIC (μg/ml) of:
Range50%/90%0.030.060.120.250.51248
Susceptible (MIC ≤ 1 μg/ml) (680)Posaconazole0.03-20.25/0.531537819799100
Ravuconazole0.03-40.5/1115348599>99100
Voriconazole0.03-40.25/0.512137294>99>99100
Intermediate (MIC = 2 μg/ml) (74)Posaconazole0.06-80.5/10483774919799100
Ravuconazole0.25-40.5/20005517499100
Voriconazole0.12-40.5/200338688997100
Resistant (MIC ≥ 4 μg/ml) (17)Posaconazole0.12->80.25/10029778294949494
Ravuconazole1->82/8000006598894
Voriconazole0.25->81/200062488949494