TABLE 3.

Percentages of MIC2 or IC50 results recorded in 17 laboratories for 8 Candida spp. isolates with known low susceptibility to caspofungin and 22 isolates with normal susceptibility

Caspofungin concn (μg/ml)% MIC2 or IC50a
RPMI (MIC2)RPMI (IC50)AM3 (MIC2)AM3 (IC50)
Normal (n = 739)Low (n = 265)Normal (n = 535)Low (n = 193)Normal (n = 733)Low (n = 270)Normal (n = 513)Low (n = 198)
0.0080.00.00.00.056.56.771.28.6
0.0160.00.00.00.08.90.49.62.5
0.0324.60.49.33.622.01.511.12.5
0.06321.20.026.51.67.61.95.82.5
0.1320.70.023.65.72.73.30.45.1
0.2518.41.918.12.10.57.40.04.5
0.521.12.314.63.60.121.50.415.2
111.114.06.513.50.028.10.033.3
21.846.81.137.80.017.80.015.7
40.025.30.020.20.06.70.06.1
80.14.50.05.70.00.70.22.0
160.52.30.24.71.64.11.42.0
320.41.50.01.00.00.00.00.0
>320.01.10.00.50.00.00.00.0
  • a n = the number of results from 17 laboratories. The χ2 values for RPMI (MIC2), RPMI (IC50), AM3 (MIC2), and AM3 (IC50) were 727, 467, 784, and 529, respectively.