TABLE 2.

Unadjusted associations between GBS CCs and neonatal disease statusa

Genotype (413 strains)Pregnant women (232 strains)EOD (127 strains)bLOD (54 strains)
No. (%) of strainsORNo. (%) of strainsOR (95% CI)PNo. (%) of strainsOR (95% CI)P
CC-1 (94 strains)65 (28)1.025 (19)0.6 (0.36, 1.09)0.124 (8)0.2 (0.06, 0.63)0.08
CC-23 (89 strains)57 (25)1.030 (24)1.0 (0.55, 1.62)0.842 (4)0.1 (0.02, 0.52)0.0006
CC-19 (84 strains)39 (17)1.034 (27)2.1 (1.17, 3.63)0.00711 (20)1.3 (0.56, 2.82)0.54
CC-17 (67 strains)14 (6)1.022 (17)3.3 (1.53, 7.04)0.000731 (57)21.0 (9.20, 48.66)<0.0001
CC-12 (58 strains)42 (18)1.010 (8)0.4 (0.17, 0.84)0.0086 (11)0.6 (0.20, 1.49)0.22
Singletons (21 strains)15 (6)1.06 (5)0.7 (0.24, 2.04)0.500 (0)0.08c
  • a Differences in the distribution of CCs were tested using the likelihood ratio χ2 (1 df); OR, 95% CI, and P values were calculated relative to the combination of all other genotypes from pregnant women. “Singletons” refers to those STs not part of a CC.

  • b GBS strains identified retrospectively before 1995 (n = 4) were omitted even though they represented EOD cases.

  • c Fisher's exact test was used because no LOD cases were caused by singleton STs.