TABLE 1.

Increased MIC of polymyxin B for CRKP isolates from three patients treated with polymyxin B

Isolate sourceSample typeDate of isolation (mo/day/yr)Duration of treatment (days)Polymyxin B MIC (μg/ml)
Patient 1Peritoneal fluid3/28/2006141.5
Blood4/13/200632
Patient 2aCSFb11/5/200521c0.75
Blood11/26/200512
Patient 3Blood12/7/200550.75
Blood12/12/20051,024
  • a Received polymyxin B intrathecally and intravenously in earlier course of therapy.

  • b CSF, cerebrospinal fluid.

  • c Polymyxin was started on the day of initial isolate recovery as an empirical therapy based on prior surveillance cultures yielding CRKP.