TABLE 2.

. In vitro susceptibilities of rare and emerging species of Candida to new and established antifungal agents determined by NCCLS M27-A2 broth dilution MIC methodsa

SpeciesAntifungal agentNo. of isolates testedMIC (μg/ml)% Sb
Range50%90%
C. glabrataAmphotericin B601c0.06-161275.2
Flucytosine6010.06-80.060.1299.2
Fluconazole1,9660.12->12883261.9
Posaconazole1,9290.015->80.5286.2
Ravuconazole1,8690.007->80.25190.3
Voriconazole1,9660.007->80.25191.8
Caspofungin601d0.007-0.50.030.06100
C. kruseiAmphotericin B234c0.06-16488.0
Flucytosine2340.06->12816324.0
Fluconazole3124->12832642.9
Posaconazole3060.12-20.5199.3
Ravuconazole3020.03-20.50.599.0
Voriconazole3120.06-40.250.599.4
Caspofungin101d0.03-40.120.2599.0
C. lusitaniaeAmphotericin B103c0.06-160.25196.7
Flucytosine1030.06->1280.06889.3
Fluconazole1030.12-640.5296.1
Posaconazole1290.015-10.030.12100
Ravuconazole1030.007-40.0150.0698.1
Voriconazole1340.007-20.0070.0399.2
Caspofungin24d0.06-0.50.120.25100
C. dubliniensisAmphotericin B101c0.06-10.250.5100
Flucytosine1010.06-0.250.060.06100
Fluconazole1010.12->1280.25891.1
Posaconazole1030.015->80.030.0698.1
Ravuconazole1010.007->80.0070.0398.0
Voriconazole1030.007->80.0070.0398.1
Caspofungin71d0.03-10.250.5100
C. guilliermondiiAmphotericin B102c0.06-320.25198.0
Flucytosine1020.06-40.120.25100
Fluconazole102025->12841685.3
Posaconazole850.015-80.250.597.6
Ravuconazole1020.007->80.25197.1
Voriconazole920.007->80.060.596.7
Caspofungin27d0.06->80.5196.3
C. rugosaAmphotericin B13c0.5-321454.5
Flucytosine130.06-320.51684.6
Fluconazole190.5-3241678.9
Posaconazole190.015-0.50.060.25100
Ravuconazole130.007-0.250.0150.25100
Voriconazole190.015-0.250.0150.12100
Caspofungin3d0.12-0.50.25NDe100
  • a Data compiled from references 83 to 88.

  • b % S, percent susceptible at MICs of ≤8 μg/ml (fluconazole), ≤4 μg/ml (flucytosine), or ≤1 μg/ml (all other agents).

  • c Amphotericin B MICs were determined by Etest (80).

  • d Caspofungin MICs were read as the lowest concentration at which prominent inhibition (≈50%) is observed at 24 h of incubation (87).

  • e ND, not done.