TABLE 4.

In vitro susceptibilities of opportunistic filamentous fungi to new and established antifungal agents determined by NCCLS M38-A broth dilution MIC methodsa

SpeciesAntifungal agentNo. of isolates testedMIC (μg/ml)Reference
Range50%90%
Aspergillus terreusAmphotericin B1011-164496
Itraconazole160.25-10.50.520
Posaconazole160.06-0.250.120.2520
Ravuconazole160.03-0.50.250.520
Voriconazole1010.06-160.250.2596
Caspofungin160.015-0.120.030.0620
Anidulafungin2≤0.03≤0.03NDb24
Rhizopus spp.Amphotericin B150.06-10.5116
Itraconazole150.25-320.5416
Posaconazole150.12-10.250.516
Ravuconazole50.5->8>8ND20
Voriconazole154-6481616
Caspofungin5>8>8ND20
Absidia spp.Amphotericin B100.06-0.120.120.1216
Itraconazole100.03-0.250.060.2516
Posaconazole100.06-0.250.060.1216
Ravuconazole81-82ND62
Voriconazole102-16161616
Mucor spp.Amphotericin B70.5-11ND62
Itraconazole70.5->16>16ND62
Posaconazole60.5-21ND16
Ravuconazole71->16>16ND62
Voriconazole716->16>16ND62
Caspofungin3>8>8ND20
Fusarium spp.Amphotericin B111-21220
Itraconazole112->8>8>820
Posaconazole110.5->8>8>820
Ravuconazole110.25->88>820
Voriconazole110.25->84>820
Caspofungin11>8>8>820
Anidulafungin1216->16(>16)cNAd24
Fusarium oxysporumAmphotericin B622ND25
Itraconazole61->16(8)cND25
Voriconazole644ND25
Fusarium solaniAmphotericin B61-2(1.3)cND25
Itraconazole61->16(8)cND25
Voriconazole68-16(10.5)cND25
Scedosporium apiospermumAmphotericin B131-1641660
Itraconazole130.25-80.5460
Posaconazole130.25-21260
Ravuconazole30.25-42ND62
Voriconazole130.03-0.50.250.560
Caspofungin6NA(1.3)cND24
Anidulafungin52->16(4)eND72
Scedosporium prolificansAmphotericin B552->16>16>1660
Itraconazole55>32>32>3260
Posaconazole55>8>8>860
Ravuconazole6>16>16ND62
Voriconazole551-84460
Anidulafungin58-16(8)eND72
Terbinafine552->32163260
Acremonium spp.Amphotericin B33NA1432
Itraconazole33>10>10>1032
Voriconazole30.25-1(1)ND72
Anidulafungin31->16(>16)eND72
Paecilomyces spp.Amphotericin B60.06->80.5ND20
Itraconazole60.06-20.25ND20
Posaconazole60.03-0.50.12ND20
Ravuconazole60.03-40.25ND20
Voriconazole60.03-20.25ND20
Caspofungin60.03-80.06ND20
Anidulafungin50.03->16(8)eND72
Trichoderma spp.Amphotericin BNA1-2NANA11
ItraconazoleNA≥4NANA11
VoriconazoleNA0.25-2NANA11
Bipolaris spp.Amphotericin B60.5-1(0.6)cND25
Itraconazole6<0.03-0.12(0.06)cND25
Posaconazole60.06-0.25(0.14)cND24
Voriconazole60.12-1(0.3)cND25
Caspofungin61-2(1.7)cND24
Anidulafungin61-4(2.7)cND24
Exophiala spp.Amphotericin B52-16(2)eND72
Voriconazole50.5-2(0.5)eND72
Anidulafungin50.12-2(1)eNA72
Phialophora spp.Amphotericin B52-4(2)eNA72
Voriconazole50.12-1(1)eNA72
Anidulafungin50.03-0.25(0.12)eNA72
Wangiella spp.Amphotericin B54-≥16(4)eNA72
Voriconazole50.5-2(1)eNA72
Anidulafungin52-8(2)eNA72
  • a Testing was performed as described in reference 68.

  • b ND, not done.

  • c Geometric mean MIC.

  • d NA, not available.

  • e Median MIC.