TABLE 2.

Isolation and infection of M. intracellulare by underlying disease, sex, and agea

CategoryIsolationInfection
No. of patients with isolate/no. who had culture performed (per 100)OR (P)No. of patients with infection (per 100)dOR (P)
MenWomenBothMenWomenBoth
All21/4,161 (0.50)44/3,311 (1.33)65/7,472 (0.87)2.66 (< 0.001)11 (0.26)30 (0.91)41 (0.55)3.43 (<0.001)
Cancer statusb
    Lung cancer9/656 (1.37)6/454 (1.32)15/1,110 (1.35)0.96 (NS)5 (0.76)4 (0.88)9 (0.81)1.16 (NS)
    Not lung cancer12/3,505 (0.34)38/2,857 (1.33)50/6,362 (0.79)3.91 (<0.001)6 (0.17)26 (0.91)32 (0.50)5.32 (<0.001)
        Other solid tumors4/1,607 (0.25)19/1,529 (1.24)23/3,136 (0.73)4.96 (0.001)1 (0.06)14 (0.91)15 (0.48)14.7 (<0.001)
        Hematologic tumors7/1,706 (0.41)11/1,099 (1.00)18/2,805 (0.64)2.44 (0.056)4 (0.23)4 (0.36)8 (0.29)1.55 (NS)
        No tumor1/192 (0.52)8/229 (3.49)9/421 (2.14)6.71 (0.036)1 (0.52)8 (3.49)9 (2.14)6.71 (0.036)
Age (yr)c
    ≤493/1,228 (0.24)3/1,102 (0.27)6/2,330 (0.26)1.13 (NS)1 (0.08)1 (0.09)2 (0.09)1.11 (NS)
    50-593/977 (0.31)7/821 (0.85)10/1,798 (0.56)2.74 (NS)3 (0.31)5 (0.61)8 (0.44)1.98 (NS)
    60-698/1,120 (0.71)12/801 (1.50)20/1,921 (1.04)2.11 (NS)4 (0.36)6 (0.75)10 (0.52)2.10 (NS)
    ≥707/836 (0.84)22/587 (3.74)29/1,423 (2.04)4.45 (<0.001)3 (0.36)18 (3.07)21 (1.48)8.56 (<0.001)
  • a OR, odds ratio; NS, not significant.

  • b Odds ratios were determined for lung cancer patients versus patients without lung cancer and were as follows for the isolation group: for men, 4.03(P < 0.001); for women, 0.99 (P was not significant); for both, 1.71 (P was not significant). For the infection group, odds ratios were as follows: for men, 4.45 (P = 0.007); for women, 0.97 (P was not significant); for both, 1.61 (P was not significant).

  • c In the isolation group, the mean ages of men, women, and both combined were 63.9, 67.5, and 66.3 years, respectively. In the infection group, the mean ages of men, women, and both combined were 63.3, 69.4, and 67.8 years, respectively. For all patients who had culture performed, the mean ages of men, women, and both combined were 56.3, 55.4, and 55.9 years, respectively. Age trends were examined, and P values were determined. In the isolation group, for men, women, and both combined, P values were 0.072 (not significant), 0.001, and 0.001, respectively. In the infection group, for men, women, and both combined, P values were not significant, 0.001, and 0.001, respectively.

  • d To determine rates (%), values were compared to numbers of persons who had culture performed.