TABLE 3.

Percent susceptibility among all S. pneumoniae isolates, erythromycin-resistant isolates by genotype, and levofloxacin-resistant isolates of S. pneumoniae collected during year 1 of the PROTEKT US study (2000-2001)

Drug and breakpoint (MIC [mg/liter])% Prevalence
Total isolates (n = 10,103)Erythromycin-resistant isolates (n = 3,133)mef(A) (n = 2,157)erm(B) (n = 530)erm(B) + mef(A) (n = 304)Levofloxacin-resistant isolates (n = 81)
Erythromycin
    Susceptible (≤0.25)68.80.00.00.00.056.8
    Intermediate (0.5)0.20.00.00.00.01.2
    Resistant (≥1)31.010010010010042.0
Cefuroximea
    Susceptible (≤1)68.724.423.431.15.654.3
    Intermediate (2)2.54.54.64.33.93.7
    Resistant (≥4)28.871.172.064.590.542.0
Co-trimoxazole
    Susceptible (≤0.5)58.813.712.417.73.337.0
    Intermediate (1-2)7.38.48.510.61.07.4
    Resistant (≥4)33.977.979.171.795.755.6
Penicillin
    Susceptible (≤0.06)61.213.412.311.52.039.5
    Intermediate (0.12-1)12.520.821.029.48.619.8
    Resistant (≥2)26.365.866.859.189.540.7
Clindamycin
    Susceptible (≤0.25)90.971.598.41.55.685.2
    Intermediate (0.5)0.20.50.40.01.00.0
    Resistant (≥1)8.827.91.398.593.414.8
Tetracycline
    Susceptible (≤2)83.854.071.74.93.672.8
    Intermediate (4)0.30.50.21.51.30.0
    Resistant (≥8)15.945.528.193.695.127.2
Levofloxacin
    Susceptible (≤2)99.198.899.097.799.00.0
    Intermediate (4)0.10.20.10.60.00.0
    Resistant (≥8)0.81.10.91.71.0100
Telithromycin
    Susceptible (≤1)99.698.899.197.498.7100
    Intermediate (2)0.31.10.91.91.30.0
    Resistant (≥4)0.040.10.00.80.00.0
  • a Breakpoints are for cefuroxime axetil (oral).