TABLE 5.

Susceptibility of MBL-producing isolates to various antimicrobial agents

Antimicrobial agentaMIC (μg/ml) for organism
Enterobacteriaceae (n = 53)P. aeruginosa (n = 22)Acinetobacter spp. (n = 21)
RangeMIC50MIC90RangeMIC50MIC90RangeMIC50MIC90
Ceftazidime16->128>128>12864->128128>128128->128>128>128
Piperacillin8->12816>1284->12816>1288->12832128
Piperacillin-tazobactama≤1->1288162->1288>128≤1-32≤14
Cefepime2->1286412832->12864>12864->128128128
Cefoperazone-sulbactam32->128>128>12864->12864>128≤1-1624
Aztreonam≤1-6416322->1288324-321632
Cefmetazole>128->128>128>128>128->128>128>12864->128>128>128
Latamoxef64->128>128>128>128->128>128>128>128->128>128>128
Meropenem1->32>32>3216->3232>328->3232>32
Imipenem1->3232>321->3216328->321632
Gentamicin≤1-4≤122->8>8>8≤1->88>8
Amikacin≤4->321632≤4->321632≤4->32816
Minocycline≤4->8≤4>4>8->8>8>8≤4-≤4≤4≤4
Levofloxacin≤2->4≤24≤2->44>4≤2-4≤2≤2
Sulfamethoxazole-trimethoprim≤0.5->2≤0.5>2>2->2>2>2≤0.5->2>2>2
Chloramphenicol≤8->1616>16>16->16>16>16≤8->16>16>16
  • a Tazobactam was tested at a fixed concentration of 4 μg/ml.