TABLE 2.

Patient demographics and clinical characteristics classified by organism

Clinical characteristicResult for the following organisma:
M. abscessus (n = 27)M. massiliense (n = 11)M. bolletii (n = 2)
Gender (no. [%] of patients)
    Male8 (29.6)5 (45.5)1 (50)
    Female19 (70.4)6 (54.5)1 (50)
Median (range) age (yr)54 (10-79)27 (14-55)31 (14-48)
Median (range) BMI (kg/m2)22.5 (14.5-30.6)b24.4 (15.4-34.2)17.7 (15.0-20.4)
Type of mycobacterial infection (no. [%] of patients)
    Pulmonary23 (85.2)7 (63.6)1 (50.0)
    Disseminated3 (11.1)2 (18.2)1 (50.0)
    Skin, soft tissue1 (3.7)1 (9.1)0
    Lymphadenitis01 (9.1)0
Comorbidities (no. [%] of patients)
    Pulmonary
        Prior pulmonary MAC infection8 (29.6)00
        Bronchiectasis (preceding NTM infection)c8 (29.6)6 (54.5)0
        Asthma3 (11.1)2 (18.2)0
        COPDd1 (3.7)1 (9.1)0
        Cystic fibrosis3 (11.1)3 (27.3)0
        Primary ciliary dyskinesia01 (9.1)0
    Immunodeficiency
        IFN-γe receptor deficiency001 (50)
        IFN-γ autoantibody1 (3.7)1 (9.1)0
        Monocytopenia1 (3.7)00
        Severe combined immunodeficiency01 (9.1)0
        Job syndrome1 (3.7)1 (9.1)0
        HIVf infection000
        Unclassified3 (11.1)00
    Active systemic immunosuppression3 (11.1)01 (50)
    History of transplant01 (9.1)1 (50)
    Malignancy3 (11.1)2 (18.2)1 (50)
    History of chemotherapy2 (7.4)2 (18.2)1 (50)
    Diabetes1 (5.9)3 (27.3)0
    Autoimmune disorder2 (7.4)2 (18.2)0
Symptoms (no. [%] of patients)
    Fever5 (18.5)2 (18.2)2 (100)
    Chills and/or night sweats6 (22.2)2 (18.2)0
    Weight loss7 (25.9)3 (27.3)1 (50)
    Fatigue13 (48.2)3 (27.3)1 (50)
    Dyspnea13 (48.2)2 (18.2)1 (50)
    Cough22 (81.5)6 (54.6)1 (50)
    Hemoptysis4 (14.8)00
    Lymphadenopathy2 (7.4)3 (27.3)2 (100)
    Wound or skin lesion4 (14.8)1 (9.1)0
  • a Species classification is based on consensus agreement among all identification methods used.

  • b BMI, body mass index. Body mass index data were missing for one subject infected with M. abscessus.

  • c Specifically refers to documented bronchiectasis preceding diagnosis with an NTM infection.

  • d COPD, chronic obstructive pulmonary disease.

  • e IFN-γ, gamma interferon.

  • f HIV, human immunodeficiency virus.