Final analysis of the clinical files at day 90 of follow-up from 29 patients with host factors and a first positive GM sample

Patient no.Age (yr)Underlying diseaseaClinical criterioncMicrobiological criterionci.v. antibiotic(s)gAnti-Aspergillus i.v. antifungal(s)cOutcome at day 90 or day (D) of deathClassification at final analysis
Respiratory signsRadiologic signs≥2 GM-positive seraPCR
167MM++YesPosTZP+D75Proven IAd
260MM++YesPosAMK-TEC-FEP+D20Probable IA
367AMLb++YesPos+AliveProbable IA
42AMLb++YesPosIPM-CIP+AliveProbable IA
511SAA++NoPosTZP+D5Possible IA
749NHL+NoPosFEP-VAND1Possible IA
851NHLYesPosTZP+AlivePossible IA
944AMLYesPosTZP-VAN+AlivePossible IA
1035ALLNoPosAliveNo IFI
1138ALLNoPosAliveNo IFI
1318ALLNoPosAliveNo IFI
1463CML++YesNegCAZ-TEC+AliveProbable IAe
1551AML++YesNegAMC-VAN-CIP+AliveProbable IA
1651ALL++NoNegCRO-TOBAliveProbable IAf
1759MMYesNegFEP-AMKAlivePossible IA
1845CLLYesNegAlivePossible IA
1960NHLYesNegTZP-TOBAlivePossible IA
2051NHLYesNegTZP-TOBAlivePossible IA
2162MMYesNegAlivePossible IA
2259NHLYesNegAMX-SXTAlivePossible IA
2312ALLNoNegAliveNo IFI
2445ALLNoNegAliveNo IFI
2541NHLNoNegAliveNo IFI
2622ALLNoNegTZPAliveNo IFI
2758AMLNoNegAliveNo IFI
2848RCCNoNegAliveNo IFI
  • a MM, multiple myeloma; AML, acute myeloblastic leukemia; ALL, acute lymphoblastic leukemia; CML, chronic myeloid leukemia; NHL, non-Hodgkin's lymphoma; CLL, chronic lymphocytic leukemia; MAS, macrophage activation syndrome; RCC, renal cell carcinoma; SAA, severe aplastic anemia.

  • b Patient had an allograft.

  • c +, present; −, absent; Neg, negative; Pos, positive when at least one replicate had a Cp value of ≤43; Pos, positive with both replicates with a Cp value of ≤40 cycles.

  • d A. fumigatus in lung biopsy.

  • e A. fumigatus in bronchoalveolar lavage.

  • f GM in bronchoalveolor lavage.

  • g AMK, amikacin; AMX, amoxicillin; AMC, amoxicillin-clavulanic acid; FEP, cefepim; CAZ, ceftazidim; CRO, ceftriaxone; CIP, ciprofloxacin; ERY, erythromycin; IPM, imipenem; OFX, ofloxacin; TZP, piperacillin-tazobactam; TEC, teicoplanin; TOB, tobramycin; SXT, trimethoprim-sulfamethoxazole; VAN, vancomycin.