TABLE 1.

Clinical data on 10 Danish patients infected with Actinobaculum schaaliic

Case no.Age (yrs)SexClinical presentationSpecimens with A. schaaliiConcomitant floraPredisposing conditionsTreatment
170MUrosepsisBlood, urineNoneProstatic hyperplasiaCefuroxime and gentamicin
263MUrosepsisBloodCoagulase-negative staphylococciCarcinoma vesicaeMeropenem, gentamicin, and nephrostomy catheter
363MPyelonephritisPus from kidney cystsaNoneProstatic hyperplasia, congenital cystic kidney malformationAmpicillin, gentamicin-ciprofloxacin, and surgical drainage
49 moFCauda equine syndromeIntradural abscess with fistulation to the skinNonhemolytic streptococciSyringomyeliaPenicillin, metronidazole, and surgical drainage
570FUrosepsisBlood, urineNoneDiabetes mellitus, multiinfarct dementiaCefuroxime and gentamicin
677FCystitisUrineNoneApoplexia, ischemic heart diseaseNitrofurantoin followed by ampicillin
784MCystitisUrineNoneFracture of collum femoris, Alzheimer's diseaseCefuroxime
865FCystitisUrine (cultured twice before initiation of treatment) Aerococcus urinae Nephrectomia and pyelonephrose of remaining kidneyAmoxicillin followed by amdinocillin
984FCystitisUrine (cultured twice before initiation of treatment) Staphylococcus aureus Urinary catheter, colon carcinoma, rheumatoid arthritisSulfamethizole and a change of catheter
1065MUrosepsis, bleeding, and shockbBloodNoneParaplegia, diabetes mellitus, kidney stonesCefuroxime, ciprofloxacin, metronidazole, and nephrectomia
  • a Identified exclusively with universal 16S rRNA gene amplification/sequencing, as the bacteria were seen in a Gram stain, but the cultures were negative, probably because the patient was treated with intravenous antibiotics for 2 weeks before sampling.

  • b After endoscopic removal of kidney stones, the patient developed shock, probably resulting from urosepsis (leukocyte count, 28.5 × 109 cells/liter; C-reactive protein, 297) and bleeding from the kidney. After 2 days, the kidney had to be removed. Pathological examination of the kidney revealed hematoma, microabscesses, tubular necrosis, and chronic pyelonephritis.

  • c All patients recovered from the infection.