TABLE 1.

Caspofungin, amphotericin B, and itraconazole in vitro susceptibility data for 200 Aspergillus isolatesa

Species (no. tested)Incubation time (h)CaspofunginAmphotericin B MIC (μg/ml)Itraconazole MIC (μg/ml)
MEC (μg/ml)MIC (μg/ml)RangeG (90%)RangeG (90%)
RangeG (90%)bRangeG (90%)
A. flavus (22)240.12-20.3 (0.5)0.06-20.31 (0.5)
480.12->81.0 (0.5)0.2-21.26 (2)0.03-0.20.11 (0.2)
A. fumigatus (137)240.12->80.64 (0.5)0.12-40.31 (0.5)
480.12->80.75 (0.5)0.2-41.2 (1.0)0.03->80.71 (0.5)
A. nidulans (13)240.2-20.42 (0.5)0.2-40.44 (0.5)
480.2-40.51 (0.5)0.5-40.88 (2)0.06-0.21.6 (0.2)
A. niger (13)240.06-0.50.16 (0.2)0.06-0.50.14 (0.2)
480.12-0.50.2 (0.5)0.5-1.00.7 (1.0)0.12/1.00.48 (1.0)
A. terreus (15)240.06-0.50.12 (0.2)0.06-0.20.12 (0.2)
480.2-0.50.27 (0.5)0.5-41.4 (4)0.03-0.50.14 (0.2)
  • a Results obtained with RPMI and an inoculum size of approximately 104 CFU/ml. MIC, ≥50% inhibition for caspofungin and itraconazole.

  • b G, geometric mean; 90%, MIC90 or MEC90.