TABLE 2.

Nonsynonymous mutations in INH-susceptible and -resistant M. tuberculosis from China

Gene or gene regionNonsynonymous mutationNo. of INH-susceptible isolates (n = 50)No. of INH-resistant isolates with indicated INH MIC range (μg/ml)
0.2 ≤ MIC < 1 (n = 24)1 ≤ MIC < 10 (n = 48)MIC ≥ 10 (n = 15)
furA Ser50011
katG Completed deletion0002
Frameshift0012
Trp90Stop0010
Ser31509389
Arg463011177
Gly4910020
Arg5150010
Gly6850010
inhA promoter−15 C→T0282
−17 G→T0001
inhA Ile210011
Ile2580020
oxyR-ahpC −9 G→A0011
−10 C→T0010
−12 C→T0002
−15 C→T0010
−39 C→T0013
−48 G→A0001
kasA Met770001
Leu2450010
Gly2690101
Gly3128231
Ser3412201
Rv0340Thr1434110
Gly1495000
Val1630010
iniB Frameshift0110
Gly1922211
iniA Arg5370101
His4813211
iniC Frameshift0011
efpA Ile734321
Glu5200001