TABLE 1.

Demographic characteristics and prevalence of HPV DNA in PBMCs of pediatric HIV patients and healthy blood donors

CharacteristicNo. (%) of patients or donorsaPb
TotalHPV-posHPV-neg
Pediatric HIV patients578c49
    Mode of HIV acquisition
        Transfusion174 (23.5)13 (76.5)0.35*
        Hemophilia213 (14.3)18 (85.7)
        Vertical191 (5.3)18 (94.7)
    CD4 count/mm3
        Minimal (>500)4040.78**
        Moderate (200-500)102 (20)8 (80)
        Severe (<200)436 (14)37 (86)
    Gender
        Male405 (12.5)35 (87.5)0.68***
        Female173 (17.6)14 (82.4)
    Aged (yr)
        ≤13273 (11.1)24 (88.9)0.38****
        >13305 (16.7)25 (83.3)
Healthy blood donors19316
    Gender
        Male162 (12.5)14 (87.5)0.42***
        Female31 (33.3)2 (66.7)
    Race
        White110110.06***
        Black83 (37.5)5 (62.5)
    Aged (yr)
        20-3583 (37.5)5 (62.5)0.08****
        ≥3611011 (100)
  • a HPV-pos and HPV-neg, HPV positive and negative, respectively.

  • b Two-tailed P value for HPV positive versus HPV negative. *, by Mehta's version of Fisher's exact test for all three acquisition categories versus HPV positivity. P = 0.25 by Fisher's exact test for vertical versus transfusion/hemophilia acquired: odds ratio = 0.25 (95% exact confidence interval, 0.005 to 2.22). **, by exact Cochran-Armitage trend test. ***, by Fisher's exact test. ****, by Wilcoxon rank sum test.

  • c P= 1.00 for 8/57 versus 3/19 HPV positive in pediatric HIV patients versus healthy blood donors.

  • d Median ages, in years, with ranges in parentheses, were as follows: for total, HPV-positive, and HPV-negative pediatric HIV patients, 13.2 (2 to 29), 13.3 (10 to 18), and 13.0 (2 to 29), respectively; for total, HPV-positive, and HPV-negative healthy blood donors, 36 (23 to 71), 34 (23 to 35), and 40.5 (29 to 71), respectively.