TABLE 3.

INH-resistant M. tuberculosis isolates with mutations in two or more genes

No. of isolatesMIC range (μg/ml)Mutation(s)a
furAkatGinhA promoterinhAoxyR-ahpCkasARv0340iniBiniAiniCefpA
141559 C Delb,e−15 C→T
1161311 T InscM771
132Del−9 G→A
1>256Del−12 C→T
50.5-32S315T−15 C→T
11S315TI21T198 T Inse
12S315T−9 G→A
12S315T−39 C→T
12S315T79 T Ins
116S315T−17 G→T
116S315TI21V
116S315TG269S98 A Inse
10.5R463L
11R463LL245R
12R463LI258TeG269SR537H
14R463LV1631
116R463L−15 C→T
116S5PR463L−39 C→Te−39 C→T
21-2S315T; R463L−15 C→T
12S315T; R463L−10 C→T
132S315T; R463L−48 G→AR537H
164S315T; 1329 A−39 C→T
Ins
1>256R463L; 1559 Ins of 64 bpd,e−12 C→T;     −39 C→TE520Ve
14R463L; G491CeI258Te
12S5P−15 C→T
  • a Amino acid abbreviations: S, Ser; T, Thr; R, Arg; L, Leu; P, Pro; G, Gly; C, Cys; I, Ile; V, Val; M, Met; H, His; E, Glu. Nucleotide abbreviations: A, adenine; C, cytosine; G, guanine, T, thymidine.

  • b Deletion (Del) of nucleotide C at position 1559.

  • c Insertion (Ins) of nucleotide T at position 1311.

  • d Insertion (64 bp) at position 1559.

  • e Novel mutation.