In vitro activity of anidulafungin against 315 fluconazole-resistant clinical isolates of Candida spp.a

OrganismNo. testedCumulative % susceptible to anidulafungin at:
0.007 μg/ml0.015 μg/ml0.03 μg/ml0.06 μg/ml0.12 μg/ml0.25 μg/ml0.5 μg/ml1 μg/ml2 μg/ml4 μg/ml8 μg/ml
C. albicans 4115426695959598100
C. glabrata 11013368198100
C. krusei 1461340829799100
Candida spp.18617393939446783100
  • a Broth microdilution testing was done according to CLSI M27-A2 (10), using 24-h incubation and MIC-2 endpoint. Fluconazole resistance is defined as a MIC of ≥64 μg/ml.