TABLE 1.

katG double mutations in 87 INH-resistant M. tuberculosis isolates from China

Nucleotide no. for the first mutation in katGAmino acidSecond mutation in katGNo. (%) of isolates with mutationINH MIC range (μg/ml)Additional mutation(s) (no. of isolates)
Nucleotide no.Amino acid
G→C at position 944Ser315ThrG→T at position 1388Arg463Leu13 (14.9)1->256 oxyR-ahpC (2), inhA promoter (2), iniA (1)
G→A at position 944Ser315AsnG→T at position 1388Arg463Leu1 (1.1)16None
G→C at position 944Ser315ThrG→C at position 2053Gly685Arg1 (1.1)2None
G→C at position 944Ser315ThrA insertion at position 1329Frameshift1 (1.1)64 oxyR-ahpC (1)
G→T at position 1388Arg463LeuG→T at position 1471Gly491Cys2 (2.3)4-8 inhA (1)
G→T at position 1388Arg463LeuCG→TA at position 1543→1544Arg515Tyr1 (1.1)8None
G→T at position 1388Arg463Leu64-bp insertion at position 15591 (1.1)>256 oxyR-ahpC (1), efpA (1)