TABLE 2.

Sensitivity and specificity of five assays for detection of Leptospira antibodies, calculated using LCA

AssayModel 1 (includes clinical definition)Model 2 (includes MAT)
% Sensitivity (95% CI), predicted casesa (n = 131)% Specificity (95% CI)% Sensitivity (95% CI), predicted casesa (n = 132)% Specificity (95% CI)
ELISA89.9 (84.7-95.1)97.4 (96.2-98.6)90.7 (85.6-95.8)97.4 (96.2-98.6)
IHA81.1 (74.4-87.9)95.9 (94.4-97.5)81.5 (74.8-88.3)95.9 (94.3-97.4)
LDS94.5 (90.5-98.4)89.5 (87.1-91.8)94.8 (90.8-98.6)89.4 (87.0-91.7)
DST95.9 (92.4-99.4)99.1 (98.3-99.8)96.4 (93.0-99.7)98.2 (98.2-99.8)
MAT98.2 (95.8-100.6)96.4 (95.0-97.9)
Clinicalb98.2 (95.7-100.6)99.2 (98.6-100.0)
χ2 df 20c89.584.3
  • a For all assays, a case was considered positive if either the acute or convalescent specimen tested positive.

  • b MAT was part of the case definition and defined most cases.

  • c Goodness of fit for chi-square test with 20 degrees of freedom.