TABLE 5.

Agreement between diagnostic assays for leptospirosis in classifying cases as positive and controls as negative

Assays comparedNo. (%) of cases testing positiveaNo. (%) of controls testing negativebKappa correlation (95% CI)c
ELISA-MAT115 (86.5)604 (94.1)0.78 (0.73-0.84)
ELISA-IHA95 (71.4)597 (93.0)0.66 (0.59-0.73)
ELISA-LDS110 (82.7)559 (87.1)0.62 (0.55-0.69)
ELISA-DST112 (84.2)620 (96.6)0.86 (0.81-0.91)
IHA-MAT105 (79.0)595 (92.7)0.70 (0.63-0.76)
IHA-LDS101 (75.9)553 (86.1)0.57 (0.50-0.64)
IHA-DST101 (75.9)608 (94.7)0.73 (0.67-0.80)
MAT-LDS124 (93.2)555 (86.5)0.66 (0.60-0.72)
MAT-DST122 (91.7)614 (95.6)0.85 (0.80-0.90)
DST/LDS117 (88.0)569 (88.6)0.67 (0.61-0.74)
  • a For each assay, a case was considered positive if the acute- and/or convalescent-phase specimen(s) tested positive. Total number of cases, 133.

  • b Total number of controls, 642.

  • c A kappa correlation of ≥0.75 was considered a good agreement; a correlation of 0.45 to 0.74 was considered a fair agreement, and a correlation of <0.45 was considered a poor agreement.