TABLE 3.

Relationship between mutations in rpoB and resistance to rifamycins

MutationRifamycin derivatives to which resistance is gained
513 Glycine→leucineRifampin plus rifapentine plus rifabutin plus rifalazil
516 Aspartic acid→valineRifampin plus rifapentine
516 Aspartic acid→tyrosineRifampin plus rifapentine
526 Histidine→glutamic acidRifampin plus rifapentine
526 Histidine→leucineRifampin plus rifapentine
526 Histidine→tyrosineRifampin plus rifapentine plus rifabutin plus rifalazil
531 Serine→leucineRifampin plus rifapentine plus rifabutin plus rifalazil