TABLE 2.

Regional variation in susceptibility of BSI isolates of C. glabrata to azoles and echinocandins, 2001 to 2007

RegionAntifungal agentNo. testedMIC (μg/ml)a% of isolates that wereb:
Range50%90%SR
WestFluconazole212->1288167610
Voriconazole210.06-80.250.5915
Caspofungin210.03-0.120.030.061000c
MidwestFluconazole3681->1288646112
Voriconazole3680.015-80.252907
Anidulafungin2000.015-0.50.060.121000c
Caspofungin3450.015-40.030.06990.3c
Micafungin1780.007-0.120.0150.0151000c
NortheastFluconazole1620.5->128161284617
Voriconazole1610.015->80.2528510
Anidulafungin780.015-0.250.060.121000c
Caspofungin1600.015-0.50.030.061000c
Micafungin750.007-0.060.0150.0151000c
SouthFluconazole1201->1288645411
Voriconazole1200.007-80.2528911
Anidulafungin450.03-0.250.060.121000c
Caspofungin1180.015-0.50.030.251000c
Micafungin290.007-0.250.0150.031000c
  • a 50% and 90%, MICs encompassing 50% and 90% of isolates tested, respectively.

  • b S, susceptible; R, resistant. Breakpoints are according to CLSI document M27-S3.

  • c Isolates for which echinocandin MICs exceed 2 μg/ml are considered nonsusceptible.