TABLE 3.

MIC and time of MIC calculation

FTL no.MIC (μg/ml) at the indicated times (h) of MIC calculationc
AMBCASMICAANID5FCFLUITRAKETOVORIPOSA
2448244824482448244824482448244824482448
R-3912a,b0.2511616>16>16>16>16480.50.50.030.060.250.50.030.03<0.015<0.015
07-301b0.5416>16>16>16>16>1632>6464>640.125128>8>80.250.5
07-302b0.2511616>16>16>16>1683232320.125148480.251
07-303b0.52816>16>161616166464640.030.060.1250.5220.030.06
07-3840.521616>16>16>16>161632110.060.060.250.250.060.06<0.015<0.015
07-497b0.5216>16>16>16>16>161664220.060.50.250.50.060.125<0.0150.125
08-2888b0.125116>16>16>16>16>168320.520.060.250.50.50.030.06≤0.0150.125
  • a From a patient with cystic fibrosis.

  • b From the index case patient.

  • c AMB, amphotericin B, CAS, caspofungin; MICA, micafungin; ANID, anidulafungin; 5-FC, fluconazole; FLU, flucytosine; ITRA, itraconazole; KETO, ketoconazole; VORI, voriconazole; POSA, posaconazole.