TABLE 1.

In vitro activities of fluconazole and voriconazole against 235 clinical isolates of C. glabrata as determined by the reference BMD method and the Etest with two different media

Antifungal agentTest methodaMIC (μg/ml)b% Agree- mentc
Range50%90%
FluconazoleBMD1->128832
ET-RPG1->256166491
ET-MBE0.5->256166496
VoriconazoleBMD0.03-80.251
ET-RPG0.012-640.25193
ET-MBE0.012-640.25195
  • a The BMD method was performed according to the guidelines for the NCCLS M27-A method (7); ET-RPG, Etest with RPG agar; ET-MBE, Etest with MBE agar.

  • b 50 and 90%, MICs at which 50 and 90% of isolates tested, respectively, are inhibited.

  • c Percentage of Etest MICs (read at 48 h) that are within 2 log2 dilutions of the reference BMD MICs.