TABLE 1.

Concordance between phenotype (MIC determined by Etest) and genotype (sequencing or real-time PCR) for H. pylori strains included in the study

H. pylorianrrl genotypegyrA genotype
Wild typeMissense mutationNo dataWild typeMissense mutationNo data
Phase 1
    Development panel H. pylori strains126
        CLA-R403b37
        CLA-S86860
        FQ-R21021
        FQ-S105105c0
Phase 2
    Clinical H. pylori strains92
        CLA-R4823412
        CLA-S4421122
        FQ-R4141
        FQ-S5151
    Gastric biopsy specimens105
        CLA-R49049
        CLA-S565610
        FQ-R2626
        FQ-S7979
  • a CLA, clarithromycin; FQ, fluoroquinolone; S, susceptible; R, resistant.

  • b Clarithromycin MIC, 2 μg/ml.

  • c Sixteen strains harbored a Thr87, which confers fluoroquinolone susceptibility.