TABLE 3.

Evolutionary pattern of EV71 in VP1 protein coding region

Method of analysis and genotypeaNo. of substitutions/nucleotideMean dN/dSNo. of negative selection sitesPosition(s) of positive selection site (codon)b
SLAC
    B0.45380.097738145*
    C0.32820.044024
FEL
    B0.53478498**, 145***
    C0.356789
  • a The numbers of sequences analyzed were 46 for genotype B and 39 for genotype C.

  • b P values are indicated as follows: *, 0.0054; **, 0.0338; and ***, 0.0004.