TABLE 1.

Baseline characteristics of 522 patients with MRSA cSSSI according to the pvl gene status of the infecting pathogena

ParameterValue for indicated patient groupPb
Total (n = 522)pvl-negative MRSA (n = 57)pvl-positive MRSA (n = 465)
Demographic characteristics
    Mean age (yr) ± SD43.0 ± 14.8662.4 ± 17.2040.7 ± 12.68<0.001
    Male sex308 (59.0)31 (54.4)277 (59.6)0.478
    White race373 (71.5)47 (82.5)326 (70.1)0.062
Source of infection<0.001
    Deep/extensive cellulitis100 (19.2)21 (36.8)79 (17.0)
    Infected burn5 (1.0)4 (7.0)1 (0.2)
    Infected ulcer6 (1.1)3 (5.3)3 (0.6)
    Major abscess345 (66.1)10 (17.5)335 (72.0)
    Wound66 (12.6)19 (33.3)47 (10.1)
Geographical location<0.001
    Africa/Asia/Australia/South America23 (4.4)15 (26.3)8 (1.7)
    Europe16 (3.1)15 (26.3)1 (0.2)
    North America483 (92.5)27 (47.4)456 (98.1)
Prior antibiotic use<0.001
    ≤24 h of therapy216 (41.4)11 (19.3)205 (44.1)
    >24 h of therapy148 (28.4)28 (49.1)120 (25.8)
    No prior therapy158 (30.3)18 (31.6)140 (30.1)
MRSA risk factors
    Hospitalization in previous 6 mo80 (15.3)30 (52.6)50 (10.8)<0.001
    Antibiotic use in previous 3 mo203 (38.9)37 (64.9)166 (35.7)<0.001
    Chronic illness333 (63.8)40 (70.2)293 (63.0)0.310
    Prior MRSA infection96 (18.4)13 (22.8)83 (17.8)0.367
    Admission from nursing home9 (1.7)6 (10.5)3 (0.6)<0.001
    Surgical procedure during current stay24 (4.6)13 (22.8)11 (2.4)<0.001
    Residence in area of CA-MRSA endemicity427 (81.8)20 (35.1)407 (87.5)<0.001
Predisposing condition (diabetes)c90 (17.3)24 (42.1)66 (14.2)<0.001
Infection characteristics
    Fever (temp of >38°C)d55 (10.6)3 (5.4)52 (11.2)0.249
    WBC count of >10 × 109 cells/litere214 (43.2)13 (25.5)201 (45.3)0.007
    Baseline infection area of >100 cm2f258 (49.4)32 (60.4)226 (48.7)0.113
    Surgical procedure involving primary infection site348 (66.7)9 (15.8)339 (72.9)<0.001
Study medication1.000
    Telavancin243 (46.6)27 (47.4)216 (46.5)
    Vancomycin279 (53.4)30 (52.6)249 (53.5)
  • a Values shown are numbers (percentages) of patients, unless otherwise indicated.

  • b All P values are two sided. The P value associated with age was computed using a two-sample t test. All other P values are derived from either Fisher's exact test (for 2-by-2 tables) or its extension (for 2-by-K tables).

  • c n = 521 (history of diabetes was not recorded for 1 patient).

  • d n = 521 (baseline temperature was not recorded for 1 patient).

  • e n = 495 (baseline WBC count was not recorded for 27 patients).

  • f n = 517 (area of infection at baseline was not recorded for 5 patients).