TABLE 2.

Clinical outcomes for 522 patients with MRSA cSSSI by pvl gene status, stratified by infection severity, diabetes, patient age, and study medication

CovariateNo. of cured patients/total no. of patients (%) with indicated MRSA statusPa
pvl-negativepvl-positive
Overall (not stratified)46/57 (80.7)426/465 (91.6)0.015
Type of infection (abscess vs nonabscess)46/57 (80.7)426/465 (91.6)0.029
Baseline fever46/56 (82.1)426/465 (91.6)0.016
WBC count of >10 × 109 cells/liter41/51 (80.4)408/444 (91.9)0.002
Baseline infection area of >100 cm243/53 (81.1)425/464 (91.6)0.021
Surgical intervention46/57 (80.7)426/465 (91.6)0.118
Diabetes46/57 (80.7)425/464 (91.6)0.037
Patient age46/57 (80.7%)426/465 (91.6%)0.010
Study medication45/57 (78.9)424/465 (91.2)0.008
  • a All P values are two sided. The Cochran-Mantel-Haenszel χ2 test was used to test for differences in clinical cure rate with respect to pvl status, adjusted for covariate. Results for the Breslow-Day test of homogeneity of odds ratios across strata were not significant (P > 0.10) for any covariate except study medication (P = 0.061).