TABLE 1.

In vitro susceptibilities of filamentous fungi isolated during 2000 and 2001

Species (no. of isolates tested)Antifungal agentMIC or MECa (μg/ml)MIC or MECa range (μg/ml)% Total at ≤1 μg/ml
50%90%
A. fumigatus (256)Amphotericin110.5->896.1
Caspofungin0.030.060.015-299.2
Itraconazole120.12-287.1
Posaconazole0.250.50.03-299.6
Ravuconazole0.250.50.06-298.8
Voriconazole0.250.50.06-498.8
A. flavus (30)Amphotericin121-270.0
Caspofungin0.030.060.015-0.12100
Itraconazole0.510.25-296.7
Posaconazole0.250.50.12-1100
Ravuconazole0.510.06-1100
Voriconazole0.510.12-1100
A. niger (29)Amphotericin110.25-1100
Caspofungin0.030.060.015-0.06100
Itraconazole220.5-444.8
Posaconazole0.510.25-1100
Ravuconazole0.520.25-286.2
Voriconazole120.12-465.5
A. versicolor (20)Amphotericin121-280.0
Caspofungin0.030.120.015-490.5
Itraconazole120.12-265.0
Posaconazole0.510.06-290.0
Ravuconazole0.2510.03-295.2
Voriconazole0.510.06-295.0
A. terreus (16)Amphotericin221-437.5
Caspofungin0.030.060.015-0.12100
Itraconazole0.50.50.25-1100
Posaconazole0.120.250.06-0.25100
Ravuconazole0.250.50.03-0.5100
Voriconazole0.2510.06-0.5100
Penicillium spp. (35)Amphotericin120.12-285.7
Caspofungin0.030.120.015->897.4
Itraconazole120.25-277.1
Posaconazole0.510.06-297.1
Ravuconazole0.540.015-880.0
Voriconazole0.520.03->880.0
Fusarium spp. (11)Amphotericin121-281.8
Caspofungin>8>8>8->80
Itraconazole>8>82->80
Posaconazole>8>80.5->818.2
Ravuconazole8>80.25->818.2
Voriconazole4>80.25->818.2
Paecilomyces spp. (6)Amphotericin0.50.06->866.7
Caspofungin0.060.03-883.3
Itraconazole0.250.06-283.3
Posaconazole0.120.03-0.5100
Ravuconazole0.250.03-483.3
Voriconazole0.250.03-283.3
Rhizopus spp. (5)Amphotericin10.5-1100
Caspofungin>8>8->80
Itraconazole41->820
Posaconazole21-440
Ravuconazole>80.5->820
Voriconazole21->840
Mucor spp. (3)Amphotericin0.50.5-1100
Caspofungin>8>8->80
Itraconazole22->80
Posaconazole10.5->866.7
Ravuconazole>81->833.3
Voriconazole21->833.3
All Aspergillus (372)Amphotericin110.12->890.6
Caspofungin0.030.060.015-498.4
Itraconazole120.12->883.1
Posaconazole0.250.50.03->898.1
Ravuconazole0.2510.03->896.8
Voriconazole0.510.03->895.2
All filamentous fungi (448)Amphotericin1.02.00.06->889.3
Caspofungin0.030.120.015->892.8
Itraconazole1.02.00.06->879.0
Posaconazole0.251.00.03->894.6
Ravuconazole0.251.00.015->891.3
Voriconazole0.51.00.03->890.2
  • a The MIC is given for all agents except caspofungin, for which the MEC is given (9, 10).