Table 4.

Status of capsule, PorA, and FetA types during clonal replacement in individual carriers

VolunteerClone (time point[s])aAltered antigen(s)b
InitialReplacement
V54Y:P1.21,16:F3-7:ST8510 (November, December, February)W-135:P1.18-1,3:F4-1:ST1158 (May)All
V63Y:P1.21,16:F3-7:ST8510 (November)B:P1.7,30:F4-1:ST6604 (December)All
V138Y:P1.21,16:F3-7:ST1466 (November, December, February)29E:P1.5,2:F1-7:ST1383 (May)All
V64Y:P1.5-1,10-1:F1-3:ST767 (November, December, February)NG:P1.17,9:F1-82:ST823 (May)Minor FetA
V82Y:P1.5-1,10-1:F1-3:ST767 (November)29E:P1.21-7,16:F5-8:ST1157 (December, February, May)All
V124Y:P1.5-1,10-1:F1-3:ST767 (November, December, February)NG:P1.7,30:F4-1:ST6604 (May)All
V14029E:P1.5-1,10-26:F5-5:ST6798 (November, December, February)B:P1.22,14:F5-5:ST213 (May)Not FetA
V11529E:P1.5,2:F1-7:ST1383 (November, December)Y:P1.21,16:F3-7:ST1466 (February)All
V12029E:P1.5,2:F1-7:ST1383 (November)Y:P1.5-1,10-1:F1-3:ST767 (May)Minor PorA VR1 and FetA
V13729E:P1.5,2:F1-7 (November)B:P1.5,2:F1-5:ST8511 (February)Not PorA and minor FetA
V5029E:P1.5,2:F1-7:ST1383 (December, February)Y:P1.5-1,10-10:F4-1:ST1655 (May)Minor PorA VR1
V7029E:P1.21-7,16:F5-36:ST1157 (February)NG:P1.7,30:F1-2:ST53 (May)All
V226B:P1.22,14:F5-5:ST213 (December)NG:P1.18,25-14:Fnull:ST823 (February, May)All
V199B:P1.22,9:F5-5:ST283 (November, February)W-135:P1.18-1,3:F4-1:ST2638 (May)All
V192W-135:P1.18-1,3:F4-1:ST1617 (November)NG:P1.18-1,3:F3-6:ST3808 (December, February, May)Not PorA
V56NG:P1.7,30-3:F1-2:ST53 (November, December)29E:P1.5,2:F1-7:ST1383 (May)Minor FetA
V206NG:P1.22,1:F1-1:ST103 (November)29E:P1.5-1,10-8:F3-6:ST254 (December, February)All
V145B:P1.22,14:F5-5:ST213 (November)29E:P1.21-7,16:F5-36:NDc (December)Minor FetA
  • a Time points indicate when each strain was isolated from a particular carrier. Note that volunteers V50, V70, and V226 were noncarriers in November, while the absence of data for other time points indicates that a volunteer was not subject to sampling.

  • b All = capsule, PorA, and FetA. See Materials and Methods for a definition of minor and major variations in PorA and FetA.

  • c ND, not determined.