TABLE 2.

Frequency of antifungal resistance among Candida bloodstream infection isolates by geographic region: SENTRY Surveillance Program, 2008 to 2009

SpeciesAntifungal agentNo. (%) of isolates resistant to each antifungal agent by regiona
Asia-PacificL. AmericaEuropeN. AmericaTotal
C. albicansAnidulafungin29 (0.0)161 (0.0)414 (0.2)406 (0.0)1,010 (0.1)
Micafungin29 (0.0)161 (0.0)414 (0.2)406 (0.0)1,010 (0.1)
Fluconazole29 (3.4)161 (0.0)414 (0.0)406 (0.0)1,010 (0.1)
Posaconazole29 (0.0)161 (0.0)414 (0.0)406 (0.0)1,010 (0.0)
Voriconazole29 (0.0)161 (0.0)414 (0.0)406 (0.0)1,010 (0.0)
C. glabrataAnidulafungin7 (0.0)18 (0.0)131 (1.5)220 (3.2)376 (2.4)
Micafungin7 (0.0)18 (0.0)131 (0.8)220 (2.7)376 (1.9)
Fluconazole7 (0.0)18 (0.0)131 (2.3)220 (8.2)376 (5.6)
Posaconazole7 (0.0)18 (0.0)131 (1.5)220 (5.5)376 (3.7)
Voriconazole7 (0.0)18 (0.0)131 (0.0)220 (5.9)376 (3.5)
C. parapsilosisAnidulafungin7 (0.0)89 (0.0)103 (0.0)160 (0.0)359 (0.0)
Micafungin7 (0.0)89 (0.0)103 (0.0)160 (0.0)359 (0.0)
Fluconazole7 (0.0)89 (6.7)103 (3.9)160 (5.0)359 (5.0)
Posaconazole7 (0.0)89 (0.0)103 (0.0)160 (0.0)359 (0.0)
Voriconazole7 (0.0)89 (0.0)103 (0.0)160 (0.0)359 (0.0)
C. tropicalisAnidulafungin6 (0.0)59 (0.0)55 (0.0)98 (1.0)218 (0.5)
Micafungin6 (0.0)59 (0.0)55 (0.0)98 (0.0)218 (0.0)
Fluconazole6 (0.0)59 (1.7)55 (3.6)98 (4.1)218 (3.2)
Posaconazole6 (0.0)59 (0.0)55 (0.0)98 (2.0)218 (0.9)
Voriconazole6 (0.0)59 (1.7)55 (3.6)98 (2.0)218 (2.9)
C. kruseibAnidulafungin1 (0.0)5 (0.0)19 (0.0)15 (0.0)40 (0.0)
Micafungin1 (0.0)5 (0.0)19 (0.0)15 (0.0)40 (0.0)
Posaconazole1 (0.0)5 (0.0)19 (0.0)15 (0.0)40 (0.0)
Voriconazole1 (100.0)c5 (0.0)19 (0.0)15 (0.0)40 (2.5)
  • a Resistance is defined as an MIC > 0.5 μg/ml for anidulafungin and micafungin versus C. albicans, C. tropicalis and C. krusei, an MIC > 4 μg/ml versus C. parapsilosis, an MIC > 0.5 μg/ml for anidulafungin and an MIC > 0.12 μg/ml for micafungin and C. glabrata, an MIC > 4 μg/ml for fluconazole versus C. albicans, C. tropicalis, and C. parapsilosis an MIC > 32 μg/ml versus C. glabrata, and an MIC > 2 μg/ml for posaconaole and voriconazole for all species. L., Latin; N., North.

  • b All isolates of C. krusei were defined as resistant to fluconazole as per CLSI criteria.

  • c Represents one isolate only.