TABLE 3.

In vitro susceptibilities of bloodstream Candida spp. isolates in the EIEIO program, July 1998 to June 2001

Species (no. of isolates tested)Antifungal agentMIC (μg/ml)a% Resistantb
Range50%90%
All Candida species (254)Amphotericin B0.25-2.01.01.0
5-FC0.06->128.00.121.03.6
Fluconazole0.12-128.00.258.02.8
Itraconazole0.007->8.00.061.011.0
Posaconazole0.007->8.00.030.5
Ravuconazole0.007-8.00.0070.25
Voriconazole0.007-8.00.0070.25
C albicans (148)Amphotericin B0.25-1.01.01.0
5-FC0.06->128.00.251.02.7
Fluconazole0.12-2.00.250.50
Itraconazole0.007-0.250.030.060
Posaconazole0.007-0.120.0150.06
Ravuconazole0.007-0.060.0070.015
Voriconazole0.007-0.250.0070.015
C. glabrata (51)Amphotericin B0.25-1.01.01.0
5-FC0.06-16.00.120.120
Fluconazole1-28.08.032.09.8
Itraconazole0.06->8.01.02.052.9
Posaconazole0.06->8.00.51.0
Ravuconazole0.03-8.00.251.0
Voriconazole0.03-8.00.121.0
C. tropicalis (28)Amphotericin B0.5-1.01.01.0
5-FC0.06->128.00.2516.07.1
Fluconazole0.25-2.00.52.00
Itraconazole0.015-1.00.120.253.6
Posaconazole0.015-0.250.060.12
Ravuconazole0.007-0.250.030.12
Voriconazole0.007-0.120.030.06
C. parapsilosis (17)Amphotericin B1.0-2.01.02.0
5-FC0.06-0.250.120.250
Fluconazole0.25-1.00.51.00
Itraconazole0.015-0.250.120.250
Posaconazole0.015-0.120.060.12
Ravuconazole0.007-0.030.0150.03
Voriconazole0.007-0.030.0150.03
  • a 50% and 90%, MIC50 and MIC90, respectively.

  • b Percent resistant according to NCCLS breakpoints (10).