TABLE 2.

Comparison of biofilm production by bloodstream isolates and clinical characteristics of candidemia

Candida speciesNo. biofilm positive/total no. for given category (%)
TotalNo. of positive blood culturesCVC-related candidemiaTotal parenteral nutritionClinically significant diseaseOutcome of candidemia
1≥2NoYesNoYesNoYesClearedUncleared
C. albicans2/30 (7)2/15 (13)0/15 (0)1/13 (8)1/17 (6)1/18 (6)1/12 (8)1/2 (50)1/28 (4)1/19 (5)1/11 (9)
All non-C. albicans56/71 (79)14/22 (64)42/49 (86)a16/29 (55)40/42 (95)a22/35 (63)34/36 (94)a5/12 (42)51/59 (86)a45/57 (79)11/14 (79)
    C. parapsilosis30/35 (86)8/13 (62)22/22 (100)a7/12 (58)23/23 (100)a11/16 (69)19/19 (100)a3/8 (38)27/27 (100)a27/32 (84)3/3 (100)
    All othersb26/36 (72)6/9 (67)20/27 (74)9/17 (53)17/19 (89)a11/19 (58)15/17 (88)a2/3 (67)24/32 (75)18/25 (72)8/11 (72)
  • a P < 0.05, significant difference between a Candida species and all other Candida species within a given category (i.e., number of positive blood cultures, 1 versus ≥2; CVC-related candidemia, yes versus no; clinically significant disease, yes versus no; outcome of candidemia, cleared versus uncleared).

  • b All Candida species other than C. albicans or C. parapsilosis included 18 C. tropicalis, 8 C. glabrata, 5 C. guilliermondii, 3 C. pelliculosa, and 2 C. lipolytica isolates.