TABLE 1.

C. albicans isolates included in this studya

PtIsolatebFluconazole MICcMechanism(s) of resistancedCaspofungin MICsc obtained with the following medium:
RPMI 1640AM3
7412S<0.125/0.50.5/1<0.015/<0.015
2307R16/>64ERG11 and CDR0.25/1<0.015/<0.015
91002S0.25/0.250.25/1<0.015/<0.015
2823R>64/>64ERG11 and MDR10.25/0.5<0.015/<0.015
3795R>64/>64 ERG11 0.25/1<0.015/<0.015
14580S1/40.25/0.5<0.015/<0.015
2440R32/64ERG11 and MDR10.5/05<0.015/<0.015
2500R32/64ERG11 and MDR10.5/1<0.015/<0.015
15945S4/8D116E and G450E1/2<0.015/<0.015
1619R32/64D116E, G450E, and G307S, ERG111/1<0.015/<0.015
163107S2/4Y132F0.5/0.5<0.015/<0.015
3119R64/>64Y132F, MDR10.5/0.5<0.015/<0.015
3120R32/>64Y132F, MDR10.25/0.5<0.015/<0.015
3184R64/64Y132F, CDR0.5/1<0.015/<0.015
3281R32/64Y132F, CDR0.5/1<0.015/<0.015
285044S4/4D446N0.5/1<0.015/<0.015
5052R32/64D446N, MDR1 and CDR0.5/1<0.015/<0.015
305106S4/80.5/1<0.015/<0.015
5108R32/64G464S, ERG11, MDR1, and CDR0.25/0.5<0.015/<0.015
421691S0.25/0.250.25/0.25<0.015/<0.015
3731R>64/>64F126L and K143R, MDR10.25/0.25<0.015/<0.015
3733R64/64F126L and K143R, MDR10.25/0.25<0.015/<0.015
431649S0.25/0.50.5/0.25<0.015/<0.015
3034R>64/>64MDR1 and CDR0.5/1<0.015/<0.015
512274SDD16/16S405F0.5/0.5<0.015/<0.015
2257R32/64S405F0.25/0.5<0.015/<0.03
2339R16/64S405F, CDR0.25/0.25<0.015/<0.015
593917S2/4F449S0.25/0.5<0.015/<0.015
4617R32/64F449S and T229A, MDR1 and CDR0.25/0.25<0.015/0.03
4639R64/>64F449S and T229A0.25/0.25<0.015/<0.015
644018S1/40.25/0.5<0.015/<0.015
4380R32/64 CDR 0.5/0.5<0.015/<0.015
  • a Serial isolates (matched susceptible and resistant) of C. albicans from patients with oropharyngeal candidiasis. Pt, patient.

  • b Letters in isolate designations signify the following: S, susceptible; SDD, susceptible (dose dependent); R, resistant.

  • c Values are in micrograms per milliliter. Two MIC values are given for each isolate: the value to the left of the shill is the value obtained after 24 h of incubation and the value to the right of the shill is the value obtained after 48 h of incubation.

  • d Underlying mechanism(s) (i.e., amino acid substitutions in Erg11p and/or genes subject to upregulation) responsible for azole resistance. Only amino acid substitutions with a demonstrated effect on azole resistance are listed. See reference 8 for a detailed analysis of molecular mechanisms of azole resistance in this series of isolates.