Table 3.

Trends in susceptibility of Candida bloodstream infection isolates to caspofungin: comparison of ECVs with the CLSI clinical breakpoint MICs

Species (ECV [μg/ml])YrNo. of isolates testedMIC (μg/ml)% of MICs
RangeMode>ECV>2 μg/ml
C. albicans (0.12)20011,0000.007–0.250.030.10.0
20021,2080.007–0.120.0070.00.0
20031,1780.007–0.250.030.10.0
20041,1190.007–0.250.030.40.0
20051,0450.007–0.120.030.00.0
20068690.007–0.50.030.20.0
20077490.007–0.120.030.00.0
20086500.007–0.120.030.00.0
20095600.007–0.250.030.40.0
C. glabrata (0.12)20012870.015–40.031.40.3
20023320.007–0.50.031.50.0
20032910.015–0.50.030.30.0
20042520.015–0.50.031.20.0
20052910.015–80.032.10.3
20062380.015–0.50.031.30.0
20072390.015–0.50.030.40.0
20082470.015–80.032.00.4
20091750.015–80.031.70.6
C. tropicalis (0.12)20011740.007–0.250.030.60.0
20022650.007–10.031.90.0
20032680.007–0.120.030.00.0
20042110.007–>80.031.90.5
20052270.007–0.250.0150.90.0
20062030.007–0.120.030.00.0
20072080.007–0.120.030.00.0
20081610.007–0.060.030.00.0
20091240.007–0.50.0150.80.0
C. krusei (0.25)2001500.06–10.2512.00.0
2002730.06–10.128.20.0
2003650.03–20.0618.50.0
2004530.015–0.50.067.50.0
2005590.06–10.125.10.0
2006340.06–0.250.120.00.0
2007940.06–0.50.061.10.0
2008400.06–10.065.00.0
2009350.03–0.250.120.00.0
C. parapsilosis (1)20012060.06–20.250.50.0
20022750.06–40.50.70.4
20033600.015–20.50.80.0
20042840.06–40.52.11.8
20052430.06–20.252.50.0
20062090.06–20.251.40.0
20072200.03–10.250.00.0
20082360.015–20.252.50.0
20091620.015–40.53.10.6