Table 4.

Trends in susceptibility of Candida bloodstream infection isolates to anidulafungin and micafungin: comparison of ECVs with the CLSI clinical breakpoint MICs

Antifungal agent and species (ECV [μg/ml])YrNo. of isolates testedMIC (μg/ml)% of MICs
RangeMode>ECV>2 μg/ml
Anidulafungin
    C. albicans (0.12)20041,1200.007–0.250.030.90.0
20051,0450.007–0.250.030.10.0
20068690.007–10.030.20.0
20077490.007–0.120.030.00.0
20086500.007–0.120.030.00.0
20095600.007–20.0150.40.0
    C. glabrata (0.25)20042520.03–10.060.40.0
20052910.03–40.120.70.3
20062380.015–0.50.060.40.0
20072390.015–0.250.060.00.0
20082470.015–20.061.20.0
20091750.015–20.061.80.0
    C. tropicalis (0.12)20042110.007–20.032.80.0
20052270.007–20.031.80.0
20062030.007–0.120.030.00.0
20072080.007–0.120.030.00.0
20081610.007–0.250.030.60.0
20091240.007–0.120.0150.00.0
    C. krusei (0.12)2004530.015–0.120.030.00.0
2005590.015–0.50.061.70.0
2006340.03–0.120.030.00.0
2007940.03–0.250.031.10.0
2008400.03–0.120.030.00.0
2009350.015–0.060.030.00.0
    C. parapsilosis (4)20042840.5–420.03.9
20052430.5–420.012.1
20062090.25–420.07.2
20072200.25–420.06.8
20082360.015–420.05.9
20091620.015–410.03.7
Micafungin
    C. albicans (0.03)20049430.007–0.120.0157.10.0
20051,0450.007–0.060.0151.30.0
20068690.007–0.50.0150.70.0
20077490.007–0.250.0150.90.0
20086500.007–0.060.0150.20.0
20095600.007–10.0152.20.0
    C. glabrata (0.03)20042000.007–0.250.0153.00.0
20052910.007–10.0153.10.0
20062380.007–0.030.0150.00.0
20072390.007–0.060.0150.80.0
20082470.007–20.0151.60.0
20091750.007–20.0151.20.0
    C. tropicalis (0.12)20041760.007–10.032.30.0
20052270.007–10.030.40.0
20062030.007–0.250.0152.00.0
20072080.007–0.060.0150.00.0
20081610.007–0.120.030.00.0
20091240.007–0.250.0150.80.0
    C. krusei (0.12)2004420.015–0.250.062.40.0
2005590.015–0.120.060.00.0
2006340.03–0.250.0611.80.0
2007940.015–0.250.061.10.0
2008400.03–0.120.060.00.0
2009350.03–0.250.065.70.0
    C. parapsilosis (4)20042430.25–210.00.0
20052430.25–210.00.0
20062090.25–210.00.0
20072200.06–210.00.0
20082360.015–210.00.0
20091620.015–813.16.2