TABLE 2.

GEE results; estimated regression coefficients and statistical values of significance for comparison to standard

Antimicrobial agentEstimated regression coefficients and significancea
Site-related differencesbMethod-related differencesc
Site 2Site 3PML MH HTMMH LHB NADIST LHB NADIST HTM
EstimateP valueEstimateP valueEstimateP valueEstimateP valueEstimateP valueEstimateP value
Amox-clav acidd −0.4600 <0.0001−0.28500.0934 0.4550 <0.0001 0.2600 <0.00010.13190.0046 0.2733 <0.0001
Azithromycin −0.5550 <0.0001 −0.3175 0.0067 0.2575 0.00040.1550<0.00010.09000.13460.15000.0188
Cefaclor −1.4250 <0.0001 −0.6875 0.0005 1.2875 <0.0001 0.4750 <0.0001−0.03000.6856−0.16000.0690
Cefixime −0.7786 <0.0001 −0.4607 0.0078 0.8893 <0.00010.2214<0.0001−0.10000.1556−0.15710.0287
Cefprozil −1.2250 <0.0001 −0.9575 <0.0001 1.0275 <0.0001 0.5350 <0.0001−0.24000.0020−0.07000.3047
Ceftriaxone −0.5000 <0.0001−0.27000.0901 0.5300 <0.00010.01000.7455−0.02000.7387−0.11000.0134
Cefuroxime −0.7900 <0.0001 −0.8550 <0.0001 0.7520 <0.00010.22000.0001−0.09000.0673−0.08000.1122
Chloramphenicol −0.8100 <0.0001−0.26500.0974 0.5850 <0.00010.14000.0001−0.01000.80830.01000.7629
Ciprofloxacin−0.02000.09790.00001.00000.05000.03100.00001.00000.08000.00890.2300<0.0001
Clarithromycin−0.2300<0.00010.14500.20440.08500.0821−0.04000.2734−0.02000.69470.04000.4917
Doxycycline −0.4700 <0.00010.01000.9278 0.4600 <0.0001−0.10000.0003 0.3800 <0.0001 0.9100 <0.0001
Erythromycin −0.4900 <0.0001−0.03000.7874 0.3200 <0.00010.1500<0.00010.08000.1660−0.01000.8694
Gemifloxacin0.00001.00000.00001.0000−0.02000.1531−0.03000.07860.01000.31490.04000.0979
Grepafloxacin−0.07500.00020.09250.15510.07750.0049−0.07500.00020.05000.2218 0.4800 <0.0001
Levofloxacin−0.05500.0056−0.01750.69020.04750.0352−0.01500.17580.2300<0.0001 0.4500 <0.0001
Ofloxacin−0.07500.0010−0.02250.70530.11250.0004−0.00500.7053 0.3500 <0.0001 0.5300 <0.0001
Trovafloxacin−0.04500.0786−0.02750.7171−0.01250.6951−0.1150<0.00010.12000.0199 0.4200 <0.0001
  • a Boldface, significant at >0.25-dilution difference. Regression coefficients are shown as doubling dilution differences above (positive values) or below (negative values) standard, and statistical values of significance (P values are compared to standard).

  • b Compared to site 1.

  • c Compared to MH HTM.

  • d Amox-clav acid, amoxicillin-clavulanic acid.