TABLE 1.

Geometric mean MICs and standard deviations (doubling dilutions) for each method for agents with unimodal populations and >90% of endpoints on scale

Antimicrobial agentMIC (μg/ml)a
Frozen MH HTMIn-house MH HTMPML MH HTMMH LHB NADIST LHB NADIST HTM
Site 1Site 1Site 2Site 3Site 1Site 1Site 2Site 3Site 3
MeanSDMeanSDMeanSDMeanSDMeanSDMeanSDMeanSDMeanSDMeanSD
Amox-clav acidb1.181.521.051.440.6971.2990.8291.1181.0071.311.731.30.9081.120.9071.2111.2
Azithromycin1.6020.840.9380.8720.5250.7280.6740.7690.6830.8210.8590.980.6930.6930.7170.7450.7470.713
Cefaclor10.631.7110.481.4213.581.3836.2331.6799.1261.33113.361.4885.4261.6356.1051.4135.5791.367
CefdinirNDcNAa0.5361.1760.2911.060.480.7360.5141.1180.5951.2340.4091.1040.5660.6720.5250.537
Cefixime0.0421.0020.0511.0080.02980.9560.0370.9330.0550.9820.0581.0140.0350.9610.0340.9560.0330.918
Cefprozil7.8351.657.5681.4892.8091.363.631.6766.1481.3989.5141.544.6911.7283.0741.5623.4581.444
CeftriaxoneNA NA 0.0081.1570.00580.9450.00691.0830.0091.1250.0081.0930.0060.9710.0071.070.0060.986
Cefuroxime1.2571.691.7781.3260.9011.140.921.0851.5911.1461.8151.4141.1971.2680.8651.1490.8710.985
Chloramphenicol0.5471.380.7681.2130.41751.2030.6241.2460.6421.250.8071.2370.4831.2580.621.20.6290.12
Ciprofloxacin0.0170.360.0160.2430.01580.20.0160.2430.0160.2930.0160.2430.0160.20.0170.3560.0190.468
Clarithromycin8.1120.8996.8690.8945.2780.7917.210.7965.8970.8336.0210.9115.6960.817.1110.8057.0130.8
Doxycycline0.5740.710.5700.7880.42340.8780.5820.7860.5740.7790.5470.8250.3840.8740.7580.8291.0940.787
Erythromycin8.1680.815.2420.7773.3870.744.8910.7564.4380.7835.2780.8654.1410.7575.1690.84.8570.726
Gemifloxacin0.0090.450.0080.2430.0080.2430.0080.2430.0080.140.0080.10.0080.10.0080.2610.0080.367
Grepafloxacin0.0170.530.0090.4650.0080.2930.0090.5050.0090.4280.0080.2930.0080.2430.010.5630.0130.661
Levofloxacin0.0280.440.0170.3210.0160.2230.0160.2930.0170.3080.0160.2930.0160.20.0190.4820.0220.559
Ofloxacin0.0540.540.0350.4350.0330.3080.0340.3930.0360.4650.0350.4350.0330.2930.0440.5770.0490.555
Trovafloxacin0.0180.630.00980.5660.0090.520.0090.5520.0090.5390.0090.50.0090.420.010.6030.0130.704
  • a For an agent with a geometric mean MIC of 4 μg/ml and an SD of one doubling dilution, the MIC range ±1 SD is 2 to 8 μg/ml and the MIC range ±2 SD is 1 to 16 μg/ml; if the SD is 0.5 doubling dilution, the MIC range ±1 SD is 2.8 to 5.7 μg/ml and the MIC range ±2 SD is 2 to 8 μg/ml.

  • b Amox-clav acid, amoxicillin-clavulanic acid, shown as amoxicillin component.

  • c ND, not determined.

  • d NA, not applicable due to >10% off-scale endpoints.