Table 1.

Evaluation of the performance of the CLSI agar dilution method for S. pneumoniae ASTc

DrugNo. of isolates% EA (no. of isolates that agree/total no. of isolates)a% CA (no. of isolates that agree)% error rate (no. of isolates that disagree)
TotalSIRVMEMEMiE
Ceftriaxone
    Meningitis13260284488.9 (72/81)53.8 (71)13.6 (6)041.7 (55)
    Nonmeningitis1328739686.6 (71/82)68.2 (90)0031.8 (42)
Clindamycin13182247N/Ab93.1 (122)2.1 (1)3.7 (3)3.8 (5)
Erythromycin13148182N/A97.7 (128)2.4 (2)00.8 (1)
Levofloxacin131104621N/A98.5 (129)001.5 (2)
Meropenem131602645N/A84.0 (110)0016.0 (21)
Penicillin
    Oral penicillin V13138266798.0 (99/101)87.8 (115)0012.2 (16)
    Parenteral
        Meningitis13138N/A9398.0 (99/101)96.9 (127)3.2 (3)2.6 (1)N/A
        Nonmeningitis1319832198.0 (99/101)85.5 (112)0014.5 (19)
Chloramphenicol131120N/A1190.7 (88/97)99.2 (130)00.8 (1)N/A
Tetracycline13262268N/A97.7 (129)002.3 (3)
Telithromycin13213110N/A84.8 (112)N/A015.2 (20)
TMP-SMX129302079N/A97.7 (126)002.3 (3)
Vancomycin132132N/AN/AN/A100 (132)N/A0N/A
  • a The denominators of the essential agreement (EA) were less than the total number of the isolates tested because MIC results of some isolates were out of the drug concentration ranges, and thus, the EA cannot be determined.

  • b The EA cannot be determined because the MIC results were out of the drug concentration ranges.

  • c S, susceptible; I, intermediate, R, resistant; EA, essential agreement, CA, category agreement; VME, very major error, ME, major error, MiE, minor error; N/A, not available; TMP-SMX, trimethoprim-sulfamethoxazole.