TABLE 1.

Voriconazole and caspofungin MIC ranges and MIC50 and MIC90 values for the isolates by the NCCLS (at 48 h), EUCAST (at 24 h), and E-test (at 48 h) methods

Species (no. of isolates)MethodVoriconazoleCaspofungin
Range (mg/liter)MIC50 (mg/liter)MIC90 (mg/liter)Range (mg/liter)MIC50 (mg/liter)MIC90 (mg/liter)
C. albicans (31)NCCLS0.008-0.0310.0160.0160.125-0.50.250.5
EUCAST≤0.004-0.0160.0080.0080.063-0.50.1250.25
E-test≤0.04-0.0160.0080.0160.032-0.250.1250.25
C. glabrata (17)NCCLS0.25-40.540.5-111
EUCAST≤0.063-0.50.250.50.25-0.50.50.5
E-test0.25-8180.250.250.25
C. parapsilosis (12)NCCLS0.008-0.0630.0160.0310.5->1612
EUCAST0.008-0.0160.0160.0160.5-212
E-test0.004-0.1250.0160.0320.25-211
C. tropicalis (11)NCCLS0.031-0.1250.0630.1250.125-0.50.250.5
EUCAST0.016-0.1250.0630.1250.125-0.50.250.25
E-test0.032-0.50.1250.1250.064-0.250.250.25
C. lusitaniae (7)NCCLS0.008-0.0310.0161-22
EUCAST0.008-0.0160.0080.5-11
E-test0.004-0.0320.0160.25-10.5
C. krusei (5)NCCLS0.25-0.50.511
EUCAST0.125-0.50.511
E-test0.25-1111
C. guilliermondii (4)NCCLS0.063-0.1250.1252->16>16
EUCAST0.031-0.1250.1251->16>16
E-test0.064-0.50.1251->321
Candida speciesa (6)NCCLS0.016-0.50.1250.5-21
EUCAST0.008-0.250.1250.125-10.5
E-test0.016-0.50.0640.125-0.50.25
Saccharomyces cerevisiae (9)NCCLS0.031-0.250.12511
EUCAST0.063-0.250.12511
E-test0.032-0.250.1250.25-0.50.5
  • a C. dubliniensis, C. famata, C. inconspicua, C. kefyr, and C. norvegensis.