TABLE 1.

Distribution of embB306 alleles among EMB-susceptible M. tuberculosis strains with different resistance profilesa

embB306 allelebNo. of strains (no. in Beijng family)
SusceptibleSHRSHSRSHRTotal
ATG-Met (wt)43 (11)14 (4)13 (2)11 (4)5 (1)29 (19)104 (41)
BTG-Val/Leu1 (1)23 (21)24 (22)
ATH-Ile1 (1)15 (5)17 (6)24 (12)
Total43 (11)15 (5)23 (2)17 (10)5 (1)69 (46)154 (75)
  • a Drug resistance abbreviations: S, STR; H, INH; R, RIF; e.g., SHR means resistance to STR, INH, and RIF.

  • b embB306 alleles: wt, wild type; BTG, any mutation in the first base of embB306; ATH, any mutation in the third base of embB306 (according to the degenerated-base code, B represents G, C, or T and H represents A, C, or T).