TABLE 1

Test results for California serogroup viruses and other arboviruses in cerebrospinal fluid and acute- and convalescent-phase serum samplese

Test name and virusTesting locationAcute-phase serum resulta (titer)Acute-phase CSF resulta (titer)Convalescent-phase serum resultb (titer)
Jamestown Canyon virus
IgM EIAMDHPreliminary positiveTNPPreliminary positive
IgM EIACDCEquivocalTNPTNP
PRNTCDCPositive (1:2,560)cPositive (1:16)dPositive (1:2,560)c
Snowshoe hare virus
IgM EIACDCNegativeTNPTNP
PRNTCDCPositive (1:20)cTNPPositive (1:20)c
La Crosse virus
IgM IFAMayoTNPNegativeTNP
IgG IFAMayoTNPNegativeTNP
IgM IFAMDHAtypicalTNPTNP
IgM EIAMDHNegativeTNPTNP
IgM EIACDCEquivocalTNPTNP
PRNTCDCPositive (1:20)cNegativePositive (1:20)c
West Nile virus
IgM EIAMDHNegativeTNPNegative
IgM EIAMayoNegativeNegativeTNP
IgG EIAMayoNegativeNegativeTNP
Real-time PCRMDHNegativeTNPNegative
Real-time PCRMayoTNPNegativeTNP
Powassan virus
IgM EIAMDHNegativeTNPNegative
Saint Louis encephalitis virus
IgM IFAMDHAtypicalTNPNegative
IgM EIAMDHNegativeTNPTNP
IgM IFAMayoTNPNegativeTNP
IgG IFAMayoTNPNegativeTNP
Eastern equine encephalitis virus
IgM IFAMDHAtypicalTNPNegative
IgM EIAMDHNegativeTNPTNP
IgM IFAMayoTNPNegativeTNP
IgG IFAMayoTNPNegativeTNP
Western equine encephalitis virus
IgM IFAMDHAtypicalTNPNegative
IgM IFAMayoTNPNegativeTNP
IgG IFAMayoTNPNegativeTNP
California group encephalitis viruses
IgM IFAMDHAtypicalTNPNegative
  • a Sample collected approximately 1 week following symptom onset.

  • b Sample collected approximately 4 weeks following symptom onset.

  • c PRNT serum titer of <1:10 is negative.

  • d PRNT CSF titer of <1:2 is negative.

  • e CSF, cerebrospinal fluid; EIA, enzyme immunoassay; MDH, Minnesota Department of Health; CDC, Centers for Disease Control and Prevention; TNP, test not performed; PRNT, plaque reduction neutralization test; IFA, immunofluorescence antibody assay; IgM, immunoglobulin M; IgG, immunoglobulin G.