Comparative analysis of SHC testing of 1,406 archived human serum samples with treponemal (TR) testing only, and with the laboratory test panel consensus that includes both TR and NTR results

SHCAssay results
Treponemal onlyaTest panel consensusb
  • a Treponemal assays include TP-PA, EIA, and CIA platforms. Sensitivity was 0.887 (95% CI, 0.862, 0.909), and specificity was 0.931 (95% CI, 0.909, 0.949).

  • b Test panel consensus refers to results that were either reactive by both treponemal and nontreponemal (RPR) tests or nonreactive by both treponemal and nontreponemal tests; discordant treponemal and nontreponemal results were excluded from analysis. Sensitivity was 0.957 (95% CI, 0.936, 0.972), and specificity was 0.932 (95% CI, 0.910, 0.951).