TABLE 1

Tests relevant to infectious disease included in the first WHO Essential Diagnostics Lista

CategoryTests used in:
Primary health care facilitiesHealth care facilities with clinical laboratories (additional tests)
GeneralGeneral microscopyCulture/blood culture
Urine dipstick/microscopyDrug susceptibility testing
Complete blood countComprehensive metabolic panel
Whole-blood lactateBlood gas testing
GlucoseC-reactive protein
Urinalysis (automated analyzer)
Disease specific (for infectious diseases)HBsAg, HBeAgHBV DNA (quantitative)
Anti-HCVIgM anti-HBc, anti-HBs
Anti-HIV, anti-HIV/p24 antigenHCV cAg
Malaria Ag (HRP2, pLDH)HCV RNA (qualitative/quantitative)
Malaria light microscopyHIV DNA/RNA (qualitative/quantitative)
TB microscopyT lymphocyte CD4 count
TB-LAMPCryptococcal antigen
Tuberculin skin testG6PD activity
Syphilis (antitreponemal)HPV DNA
Combined antitreponemal/anti-HIVTB: culture, DNA (cartridge based), LPA, DST, LAM, IGRA
Blood product testing (HBV, HCV, HIV, syphilis, Chagas disease, HTLV)
  • a Anti-HBc, hepatitis B core antibodies; anti-HBs, hepatitis B surface antibodies; CD4, cluster of differentiation 4; CMP, comprehensive metabolic panel; DST, drug susceptibility testing; G6PD, glucose-6-phosphate dehydrogenase; HBeAg, hepatitis B e-antigen; HBsAg, hepatitis B surface antigen; HBV, hepatitis B virus; HCV, hepatitis C virus; HCV cAg, HCV core antigen; HIV, human immunodeficiency virus; HPV, human papillomavirus; HRP2, histidine-rich protein 2; HTLV, human T-cell lymphotropic virus; IGRA, interferon gamma release assays; LAM, urine lipoarabinomannan; LAMP, loop-mediated isothermal amplification; LPA, line probe assay; pLDH, Plasmodium lactate dehydrogenase; TB, tuberculosis.