Pretreatment predictive factors associated with hepatocarcinogenesis in 1,922 patients with SVR after all-oral DAA regimensb

FactorUnivariate analysisMultivariate analysis
HR95% CIP valueaHR95% CIP valuea
Age (yr)
Body mass index (kg/m2)
Aspartate aminotransferase concn (IU/liter)
Alanine aminotransferase concn (IU/liter)
Platelet count (104/mm3)
Total cholesterol level (mg/dl)
Low-density lipoprotein cholesterol level (mg/dl)
Level of viremia (log IU/ml)
Alpha-fetoprotein concn (μg/liter)
WFA+M2BP level (COI)
HCV core subgroup
    HCV-1b core aa 70 wild3.000.87–10.30.08110.51.28–86.00.029
    HCV-1b core aa 70 mutant4.101.21–13.90.02319.72.51–1550.005
HCV NS5A subgroup
    HCV-1b NS5A aa 93 wild2.460.75–8.120.140
    HCV-1b NS5A aa 93 mutant4.311.17–15.90.029
  • a Significance was determined using the Cox proportional hazard model.

  • b HR, hazard ratio; CI, confidence interval. Only variables that achieved statistical significance or marginal significance on univariate analysis are shown.