TABLE 3

Posttreatment predictive factors associated with hepatocarcinogenesis in 1,922 patients with SVR after all-oral DAA regimensb

FactorUnivariate analysisMultivariate analysis
HR95% CIP valueaHR95% CIP valuea
Age (yr)
    <6611
    ≥662.041.05–3.960.0373.100.87–11.00.082
Alanine aminotransferase concn (IU/liter)
    <1511
    ≥154.161.92–9.00<0.0012.730.88–8.410.081
Platelet count (104/mm3)
    <20.01
    ≥20.00.310.12–0.780.013
Alpha-fetoprotein concn (μg/liter)
    <511
    ≥53.331.72–6.43<0.0013.441.20–9.830.021
WFA+M2BP level (COI)
    <1.011
    ≥1.010.33.01–35.1<0.0014.941.37–17.80.014
  • a Significance was determined using a Cox proportional hazard model.

  • b HR, hazard ratio; CI, confidence interval. Only variables that achieved statistical significance or marginal significance on univariate analysis are shown.