TABLE 4

Sensitivity, specificity, positive predictive value, and negative predictive value of FP-VLP-MAC-ELISA and NS1-MAC-ELISA for the validation serum panel based on the developed algorithma

AssayDisease statusDisease prevalenceSensitivitySpecificityPPVNPV
FP-VLP-MAC-ELISAZIKV33.30 (21.7–46.7)100 (83.2–100)80 (64.4–91.0)71.40 (57.4–82.3)100
DENV75 (50.9–91.3)92.50 (79.6–98.4)83.30 (62.1–93.9)88.10 (77.5–94.1)
NS1-MAC-ELISAZIKV33.30 (21.7–46.7)80 (56.3–94.3)95 (83.1–99.4)88.90 (67.1–96.9)90.50 (79.8–95.8)
DENV100 (83.2–100)92.50 (79.6–98.4)87.00 (69.2–95.2)100
  • a PPV, positive predictive value; NPV, negative predictive value. Values are percentages, with 95% confidence intervals given in parentheses.