TABLE 2

Serotype distribution within each age group during the PreVac (2009 to 2011), PostVac-I (2012 to 2014), and PostVac-II (2015 to 2017) periods in LRT samples

Serotype18–64 yrs≥65 yrs
PreVac isolates (2009–2011)PostVac-I isolates (2012–2014)PreVac vs PostVac-I p valuePostVac-II isolates (2015–2017)PreVac vs PostVac-II p valuePreVac isolates (2009–2011)PostVac-I isolates (2012–2014)PreVac vs PostVac-I p valuePostVac-II isolates (2015–2017)PreVac vs PostVac-II p value
No.No. per 100,000No.No. per 100,000No.No. per 100,000No.No. per 100,000No.No. per 100,000No.No. per 100,000
396.396.10.963117.10.8511660.31137.70.425927.80.209
410.700Nca10.60.9730000Nc00Nc
6A64.221.30.32510.60.1701245.2724.00.37126.20.037
6B32.1138.80.09553.20.6881867.8827.40.14326.20.005
6C0021.3Nc74.5Nc13.800Nc721.60.191
7F10.710.70.98810.60.97313.800Nc13.10.926
80000Nc00Nc13.800Nc00Nc
9V21.421.30.98300Nc726.400Nc00Nc
9A0000Nc00Nc27.526.90.95000Nc
9N0010.7Nc31.9Nc13.813.40.96513.10.926
11A74.964.00.824117.10.601726.4517.10.665927.80.946
1474.932.00.37900Nc830.1413.70.38113.10.068
15A0042.7Nc63.9Nc27.513.40.66226.20.895
15B/C42.832.00.78195.80.400415.1827.40.50826.20.482
16F0000Nc10.6Nc518.826.90.40100Nc
17F10.710.70.98800Nc0000Nc00Nc
18B0000Nc00Nc13.800Nc00Nc
18C10.700Nc00Nc13.800Nc00Nc
19F3927.22214.80.12674.50.00160226.145154.30.19913b40.1<0.001
19A53.564.00.97374.50.765518.8724.00.784515.40.835
200000Nc00Nc13.800Nc00Nc
210021.3Nc42.6Nc13.800Nc26.20.786
22F85.674.70.52553.20.524415.126.90.536515.40.982
23F149.864.00.26400Nc1245.2930.90.56626.20.037
23A21.432.00.98363.90.37513.813.40.965721.60.191
23B10.732.00.71542.60.388311.326.90.715618.50.638
24F0000Nc10.6Nc0000Nc13.1Nc
3110.700Nc00Nc0000Nc00Nc
33F0032.0Nc21.3Nc415.100Nc00Nc
340000Nc10.6Nc13.800Nc00Nc
35F12.153.40.27221.30.73113.8517.10.293515.40.332
35B32.121.30.74974.50.441311.3517.10.703721.60.522
Not determinedc12.132.00.51410.60.97313.800NC39.00.585
NESpd64.274.70.8862516.20.028726.41241.10.5321030.90.833
Total12385.711678.20.64112882.90.864191719.8137469.80.011102314.7<0.001
VTe6746.74731.70.176149.1<0.001107403.265222.90.0221961.7<0.001
NVTf5639.06946.50.51911473.90.00884316.672246.90.20183253.00.367
  • a Nc, not calculated.

  • b Seven isolates of serotype 19F were detected in the same patient in 2017.

  • c Serotypes other than those included in the multiplex PCR panel of the study.

  • d NESp, nonencapsulated S. pneumoniae.

  • e Serotypes detected in the study that are targeted by PHiD-CV (4, 6B, 7F, 9V, 14, 18C, 19F, and 23F).

  • f Serotypes detected in the study that are not targeted by PHiD-CV.